Journal of Intensive Care Medicine

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Free Full Text (Free PDF) Free
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Simsic, J. M.
Right arrow Articles by Michler, R. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Simsic, J. M.
Right arrow Articles by Michler, R. E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of Intensive Care Medicine, Vol. 21, No. 1, 22-26 (2006)
DOI: 10.1177/0885066605282532

Perioperative Effects and Safety of Nesiritide Following Cardiac Surgery in Children

Janet M. Simsic, MD

Heart Care International, Santo Domingo, Dominican Republic; Sibley Heart Center Cardiology, The McGill Building, 2835 Brandywine Road, Suite 300, Atlanta, GA 30341; simsicj{at}kidsheart.com

Mark Scheurer, MD

Heart Care International, Santo Domingo, Dominican Republic; Division of Pediatric Cardiology, Medical University of South Carolina, Charleston, SC

Joseph D. Tobias, MD

Heart Care International, Santo Domingo, Dominican Republic; Division of Pediatric Anesthesiology/Pediatric Critical Care, University of Missouri, Columbia, MO

John Berkenbosch, MD

Heart Care International, Santo Domingo, Dominican Republic; Division of Pediatrics/Pediatric Critical Care, University of Louisville, Louisville, KY

William Schechter, MD

Heart Care International, Santo Domingo, Dominican Republic; Department of Anesthesiology, Columbia University, New York, NY

Freddie Madera, MD

Heart Care International, Santo Domingo, Dominican Republic

Samuel Weinstein, MD

Robert E. Michler, MD

Heart Care International, Santo Domingo, Dominican Republic; Department of Cardiothoracic Surgery, Montefiore Medical Center, Bronx, NY

Nesiritide (Natrecor, Scios Inc), human B-type natriuretic peptide, has hemodynamic effects that may be beneficial in pediatric patients after cardiac surgery. Experience with nesiritide and pediatrics is limited. The purpose of this study was to evaluate perioperative effects and safety of nesiritide in pediatric cardiothoracic surgery. Seventeen patients with congenital heart disease undergoing cardiac surgery were given a loading dose (1 µg/kg) while on cardiopulmonary bypass (constant flow) followed by continuous infusion for 24 hours (0.01 µg/kg/min x 6 hours, then 0.02 µg/kg/min x 18 hours). A 7% decrease in mean blood pressure was seen following nesiritide loading dose on cardiopulmonary bypass. No patient required intervention for hypotension while receiving nesiritide load or infusion. Nesiritide load during surgery and continuous infusion after cardiac surgery in pediatric patients resulted in no significant hemodynamic compromise.

Key Words: B-type natriuretic peptide • cardiac surgery • congenital heart disease • pediatrics


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?